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KMID : 0895820100200020175
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Journal of Oriental Rehabilitation Medicine
2010 Volume.20 No. 2 p.175 ~ p.181
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Evaluation of Interaction and Safety in Administering Herb-medicine with Warfarin
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Kwon Dong-Hyun
Kim Ho-Jun
Song Mi-Young
Lee Myeong-Jong
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Abstract
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Objectives : The purpose of this study is to investigate interaction and safety in administering herb-medicine with warfarin.
Methods : For this study, we selected 19 patients who have been taking warfarin, from the ones that have been transferred from western hospital to oriental hospital. During their stay in the oriental hospital, we gave herb-medicine in addition to warfarin. Then we gathered informations and data on sex, age, main indications, and International Normalized Ratio(INR) values of selected patients through Electronic Medical Records(EMR) of Dong-Guk university hospital. Accordingly, we compiled all of the above data for a period of 10 days prior and 10 days post admission(western hospital period and oriental hospital period, respectively)
Results and Conclusions : The statistical analysis of the data have revealed that there was no significant change of INR values after giving herb-medicine with warfarin(p=0.586). The result shows that administration of herb-medicine with warfarin is safe and has little drug interaction. However, this study was carried out on small sample size and the interaction with other drugs and various kinds of herb-medicine was not considered. Although we attained a restrictive result from this study, we are able to suggest the safety about co-administration of herb-medicine and warfarin.
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KEYWORD
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Warfarin, Herb-medicine, Drug interaction
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